Description
Mixed Mode C8/SCX SPE Cartridge: Dual-Retention Sorbent for Complex Sample Extraction
The Mixed Mode C8/SCX solid-phase extraction (SPE) cartridge is designed for dual retention, combining both moderate hydrophobic interactions and strong cation exchange capabilities. The sorbent consists of octyl (C8) and sulfonic acid (SCX) functional groups proportionally bonded to a silica gel matrix.
- The C8 functional group provides moderate hydrophobic retention for non-polar and weakly polar compounds.
- The SCX (sulfonic acid) group enables strong cation exchange for positively charged analytes.
This mixed-mode cartridge is particularly useful when C18 or C8 sorbents cause excessive retention, or when SCX cartridges result in overly strong interactions that make elution difficult.
Key Features
- Balanced retention capacity, addressing elution challenges caused by single-mode sorbents
- Ideal for extracting target compounds from complex biological matrices such as blood and urine
- Provides both hydrophobic and ionic interactions, enhancing selectivity for a broader range of compounds
Applications
- Pharmaceutical and Clinical Analysis
- Detection of drugs and metabolites in biological fluids, such as acetaminophen
- Identification of substances related to drug abuse
- Forensic and Toxicology Testing
- Screening of cationic drugs and other pharmaceutical compounds from urine and blood samples
The Mixed Mode C8/SCX SPE cartridge combines the benefits of both hydrophobic and cation exchange retention, making it an effective solution for complex sample extractions in pharmaceutical, forensic, and clinical research.
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